10/8/2023 0 Comments Radnor township patrick lacey![]() The binding of RANKL to the RANK receptor on precursor cells is strictly controlled by the decoy receptor osteoprotegerin (OPG). Therefore two factors are critically involved: the macrophage-colony-simulating factor (M-CSF) and receptor activator of NF-kB ligand (RANKL), which promotes the differentiation of osteoclast precursor cells to bone-resorbing osteoclasts. In contrast to osteoblasts, which are derived from mesenchymal stem cells, osteoclasts evolve from hematopoietic stem cells. Orthodontic tooth movement (OTM) is based on multicellular processes and is characterized by remodeling of the periodontal ligament and alveolar bone due to the activity of bone-resorbing osteoclasts and bone-forming osteoblasts. ![]() ![]() NFAT-5 influences this reaction to HS, as we detected impaired OTM and osteoclast activity upon deletion. Dietary salt uptake seems to accelerate OTM and induce periodontal bone loss due to reduced bone density, which may be attributed to enhanced osteoclast activity. Deletion of NFAT-5 led to increased osteoclast activity with NS, whereas we detected impaired OTM in mice. HS promoted periodontal bone loss and OTM and was associated with reduced bone density. Osteoclast activity was increased upon HS treatment. We analyzed the expression of genes involved in bone metabolism, periodontal bone loss, OTM and bone density. We kept wild-type mice and mice lacking NFAT-5 in myeloid cells either on a low, normal or high salt diet and inserted an elastic band between the first and second molar to induce OTM. After treatment of osteoclasts without (NS) or with additional salt (HS), we analyzed gene expression and the release of tartrate-resistant acid phosphatase and calcium phosphate resorption. ![]() Here, we investigated the impact of salt and NFAT-5 on osteoclast activity and orthodontic tooth movement (OTM). Previous studies showed salt effects on periodontal ligament fibroblasts and on bone metabolism by expression of nuclear factor of activated T-cells-5 (NFAT-5). Dietary salt uptake and inflammation promote sodium accumulation in tissues, thereby modulating cells like macrophages and fibroblasts. ![]()
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